Table 9.

In vitro susceptibility to four antifungal drugsa

FungusMIC range (μg/ml) (no. of isolates tested) of:
VoriconazoleAmphotericin BFluconazoleItraconazole
Blastomyces dermatitidis s≤0.03–1 (37)≤0.03–1 (28)1–64 (30)≤0.03–1 (33)
Coccidioides immitis ≤0.03–0.125 (38)0.125–1 (27)2–64 (29)0.125–2 (27)
Histoplasma capsulatum ≤0.03–1 (39)≤0.03–2 (31)≤0.125–64 (29)≤0.03–8 (31)
Paracoccidioides brasiliensis ≤0.03–2 (19)0.125–4 (14)≤0.125–64 (14)≤0.03–1 (14)
Penicillium marneffei ≤0.03 (27)≤0.03–8 (25)1–8 (25)≤0.03–2 (25)
Pseudallescheria boydii 0.06–1 (23)2–≥16 (23)4–64 (23)1–4 (23)
Sporothrix schenckii 0.50–6 (32)0.025–2 (23)32–≥128 (23)0.25–4 (26)
Trichosporon beigeliigroup≤0.03–1 (24)0.125–≥16 (24)0.5–≥128 (24)0.125–2 (24)
  • a Adapted from reference158.