Table 4.

hsp involvement in experimentally induced autoimmune diseases

DiseaseStrainCausative agentEvidence for hsp60 involvement in diseaseMajor reference(s)
IDDMNOD miceSpontaneousTransfer of CD4 T cells specific for mycobacterial hsp60 accelerates the onset of IDDM 66
Epitope shared by mycobacterial and mammalian hsp60 is recognized by CD4 T cells causing insulitis 68
Immunization with an hsp60 peptide confers protection 65, 67, 68
Immune response to hsp60 correlates with insulitis 258
Tolerance induced to a self-hsp60 epitope in NOD mice carrying a self-hsp60 transgene 23
AALewis ratsHeat-killed M. tuberculosis Isolation of an arthritogenic T-cell clone with specificity for a nonconserved mycobacterial hsp60 peptide 293
Protection is induced by immunization with an hsp60 peptide 305
Protection against AA is induced by vaccination with hsp60-expressing vaccinia virus 177
Protection against AA is induced by immunization with a mycobacterial hsp60 peptide cross-reactive to self-hsp60 8
Administration of the mycobacterial hsp10 delays onset and severity of disease 226
Protection against AA is induced by immunization with naked DNA encoding mycobacterial hsp60 225
Intranasal tolerization to an hsp60 peptide suppresses the onset of AA 222
Protection is induced by immunization with mycobacterial hsp70 157
Pristane arthritisMicePristaneImmunization with mycobacterial hsp60 confers protection 287
Induction of disease depends on CD4 T cells specific for hsp60 270
Self hsp60 is a target for serum antibodies and T cells 16
Self-hsp60 expression is found in inflamed joints 15
Streptococcal cell wall-induced arthritisLewis ratsCell walls of streptococciImmunization with mycobacterial hsp60 confers protection against disease 291
Collagen-induced arthritisLewis ratsCollagen type IIImmunization with mycobacterial hsp60 slightly suppresses disease 22
Experimental autoimmune encephalomyelitisLewis ratsMyelin basic proteinImmunization with a peptide of the myelin protein cross-reactive with a mycobacterial hsp60 peptide protects against disease 26