Table 1.

Association of chaperones with molecules involved in antigen recognition

ChaperoneMost likely associationReference
BipHuman MHC class I molecules 54
Incompletely assembled MHC class II molecules 29
Early-folding intermediates of Ig chains 192
TCR α-chains 279
gp96MHC class II molecules in the absence of invariant chain 246
Unassembled but not assembled Ig 193
CalnexinUnassembled MHC class I molecules; retaining unassembled MHC class I α-chains in the ER 227
Assembly of intermediates of MHC class II molecules 5
Incompletely assembled TCR; retaining incompletely assembled forms of TCR in the ER 228