Table 3.

hsp-specific immune responses that confer protection against infection

PathogenProtective immune responses against hsp in microbial infectionReference
Helicobacter pylori Vaccination with GroES and GroEL homolog of H. pylori protects mice against infection and gastroduodenal disease 78
Histoplasma capsulatum Vaccination with hsp70 of H. capsulatum enhances host resistance against infection 94
Vaccination with hsp60 ofH. capsulatum protects mice against pulmonary histoplasmosis 95
Mycobacterium tuberculosis Vaccination with transgenic cell line expressing mycobacterial hsp60 protects mice against infection with M. tuberculosis 262
Adoptive transfer of αβ T cells or γδ T cells specific for mycobacterial hsp60 confers protection against infection with M. tuberculosis 263
Treatment of mice with DNA encoding the mycobacterial hsp60 protects mice againstM. tuberculosis infection 179
Treatment of mice with DNA encoding the mycobacterial hsp70 protects mice against M. tuberculosisinfection 178
Mycobacterium bovis BCGAdoptive transfer of CD8 T cells specific for mycobacterial hsp60 confers partial protection against M. bovis infection in mice 310
Plasmodium yoelii Adoptive transfer of γδ T cells specific for hsp60 of P. yoelii confers partial protection against infection with P. yoelii in mice 289
Yersinia enterocolitica Adoptive transfer of Yersiniahsp60-reactive CD4 αβ T cells mediates protection against lethal infection with Y. enterocolitica in mice 206
Immunization of mice withYersinia hsp60 induces protection against Y. enterocolitica 207