Table 13.

Parameters affecting the response of S. cerevisiae to chlorhexidinea

Parameter Role in susceptibility of cells to chlorhexidine
Cell wall composition
 MannanNo role found to date
 GlucanPossible significance: at concentrations below those active against whole cells, chlorhexidine lyses protoplasts
Cell wall thicknessIncreases in cells of older cultures: reduced chlorhexidine uptake responsible for decreased activity(?)
Relative porosityDecreases in cells of older cultures: reduced chlorhexidine uptake responsible for decreased activity(?)
Plasma membraneChanges altering CHG susceptibility(?); not investigated to date
  • a Data from references204 to 208 and436.