Table 6.

A. fumigatus molecules with a putative role in virulence

CategoryRole in vivoMoleculeReference(s)
AdhesinsPromotion of interactions of host proteins and cells with A. fumigatusComplement receptor (54–58 kDa)626
Laminin receptor (72 kDa)664
Hydrophobins (14 and 16 kDa)484, 649
PigmentsInhibition of phagocytosis of conidiaDihydroxynaphthalene-melanin284, 350, 666, 667
Toxic moleculesHost cell deathRNase (18 kDa)19, 189, 343, 344
Erythrocyte lysisHemolysin (30 kDa)179-181, 206, 207, 737-740
ImmunosuppressionSecondary metabolites, e.g., gliotoxin10, 129, 182, 632, 633, 709
EnzymesPromotion of lung matrix colonization and/or degradation of humoral factors Serine protease (33 kDa)427, 428, 641
Aspartic protease (38 kDa)521, 522
Metalloprotease (40 kDa)286, 426
Dipeptidylpeptidases (88 and 94 kDa)41, 42
Antioxidants during phagocytosisCatalases (350 kDa and unknown)89
Superoxide dismutases (27 and 67 kDa)125, 267, 268
Epithelial damagePhospholipase(s)57