Table 2.

Purified antigenic proteinsa ofA. fumigatus reported in the literature

Mol mass (kDa) from SDS-PAGEfLocalizationbBiochemical functionGene clonedRecombinant proteinReference(s)
12??++ 123
18c SRNase++ 21,126, 168, 343, 344, 349, 377, 424, 433, 434
19ICPeroxisomal protein++ 123
19c(67)d SSuperoxide dismutaseNAe 236, 267,268
20S?NA 578
27ICSuperoxide dismutase++ 123, 125,256
28S?NA 132
30??++ 123
33SSerine protease++ 287, 424, 428,435, 436, 520
34??++ 123
36 (70?)d S?++ 26, 27,87, 88, 90, 197, 239, 333, 338, 380, 504, 648
38SAspartic protease++ 424,521-523
40SMetalloprotease++ 286, 424, 426,607
82ICMetalloprotease+ 277
88c SDipeptidyl peptidase++ 41, 240, 313
90c(350)d SCatalase++ 89,252, 382
93IC?NA 243
94SDipeptidyl peptidase++ 42
  • a Antigens reacting with antibodies from immunocompetent patients with aspergillosis have been purified by biochemical or molecular biology strategies.

  • b S, secreted (including possible cell wall localization); IC, intracellular.

  • c Most discriminant antigens.

  • d The molecular mass of the native protein is indicated in parentheses.

  • e NA, not applicable.

  • f SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel electrophoresis.