Table 2.

Purified antigenic proteinsa ofA. fumigatus reported in the literature

Mol mass (kDa) from SDS-PAGEfLocalizationbBiochemical functionGene clonedRecombinant proteinReference(s)
12??++123
18cSRNase++21, 126, 168, 343, 344, 349, 377, 424, 433, 434
19ICPeroxisomal protein++123
19c(67)dSSuperoxide dismutaseNAe236, 267, 268
20S?NA578
27ICSuperoxide dismutase++123, 125, 256
28S?NA132
30??++123
33SSerine protease++287, 424, 428, 435, 436, 520
34??++123
36 (70?)dS?++26, 27, 87, 88, 90, 197, 239, 333, 338, 380, 504, 648
38SAspartic protease++424, 521-523
40SMetalloprotease++286, 424, 426, 607
82ICMetalloprotease+277
88cSDipeptidyl peptidase++41, 240, 313
90c(350)dSCatalase++89, 252, 382
93IC?NA243
94SDipeptidyl peptidase++42
  • a Antigens reacting with antibodies from immunocompetent patients with aspergillosis have been purified by biochemical or molecular biology strategies.

  • b S, secreted (including possible cell wall localization); IC, intracellular.

  • c Most discriminant antigens.

  • d The molecular mass of the native protein is indicated in parentheses.

  • e NA, not applicable.

  • f SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel electrophoresis.