Table 3.

Factors that may contribute to clinical antifungal drug resistance

Fungal factorsDrug factorsHost (and other) factors
Initial MICFungistatic nature of drugImmune status
Cell typeDosingSite of infection
 Yeast/hyphae FrequencySeverity of infection
 Switch phenotype QuantityPresence of foreign materials (dentures, catheters, prosthetic valves)
 Serotype Schedule (intermittent vs continuous) Abscess formation
Genomic stability of strain Cumulative dosePatient noncompliance with drug regimen
Size of populationPharmacokinetics
Population “bottlenecks” Absorption
Biofilms Distribution
 Metabolism
Drug-drug interactions