TABLE 3

Examples of resistance genes associated with ISEcp1 and related elements

ISaDeterminant(s)Resistance(s)b
ISEcp1cblaCTX-M-1 group3GC
blaCTX-M-2 group3GC
blaCTX-M-9 group3GC
blaCTX-M-25 group3GC
blaACC3GC, BLBLI
blaCMY-2-like genes3GC, BLBLI
blaOXA-181-like genesCarbapenems
blaOXA-204Carbapenems
Some qnrB genesFluoroquinolones (low level)
qnrE1Fluoroquinolones (low level)
rmtCAminoglycosides (high level)
IS1247aac(3)-IIf-arr(Aminoglycosides, rifampind)
ISKpn23blaBKCCarbapenems
aac(3)-IIbGEN, TOB
ISEnca1aph(2″)-IeGEN, TOB, KAN
  • a Information is available from references cited in the text as well as from other references (21, 253, 435, 508, 509) or references cited therein.

  • b 3GC, third-generation cephalosporins; BLBLI, β-lactam–β-lactamase inhibitor combinations; GEN, gentamicin; TOB, tobramycin; KAN, kanamycin.

  • c Some ISEcp1 transposition units have been assigned Tn numbers. Search the Tn registry (http://transposon.lstmed.ac.uk/) with “ISEcp1” for details.

  • d Predicted from homology to known genes.