TABLE 2

International guidelines for therapy of MRSA PVEa

ESC guidelines for adultsAHA guidelines
PediatricAdult
Vancomycin at 30–60 mg/kg Q24h i.v., BID or TID during ≥6 wkVancomycin at 40 mg/kg Q24h i.v. (maximum dose, 2 g Q24h), BID or TID during ≥6 wkVancomycin at 30 mg/kg Q24h i.v., BID during ≥6 wk
Rifampin at 900–1,200 mg Q24h i.v./orally, BID or TID during ≥6 wkRifampin at 20 mg/kg Q24h i.v. (maximum dose, 900 mg Q24h), TID during ≥6 wkRifampin at 900 mg Q24h i.v./orally, TID during ≥6 wk
Gentamicin at 3 mg/kg Q24h i.v./i.m., once a day or BID during the first 2 wkGentamicin at 3 to 6 mg/kg Q24h i.v./i.m., TID during the first 2 wkGentamicin at 3 mg/kg Q24h i.v./i.m., BID or TID during the first 2 wk
  • a The doses of these drugs must be adjusted in the setting of renal insufficiency. The intravenous (i.v.) route is preferred, particularly in infants and children. Q24h, every 24 h; BID, twice a day; TID, three times a day; i.m., intramuscular.