TABLE 6

Results with regard to maternal factors from studies investigating perinatal factors that influence vaccine responses

Type of responseVaccine response and vaccine: measurement [reference(s)]
Maternal antibodies associated with lower infant responses to vaccinationMaternal high body mass indexMaternal malnutritionAntenatal steroids
Humoral responses
  • Lower antibody production

    • HepA: GMTs (305, 306)

    • Diphtheria: GMTs (14)

    • Measles: SCRs (49)

    • OPV: titers (575)

    • ORV: SCRs (295, 296, 307310)

    • Pertussis

      •  PRN: GMTs (14)

    • IPV: GMTs (14)

    • Tetanus: GMTs (14)

  • Lower antibody production

    • OPV: SPRs (326)

    • ORV: SPRs (326)

  • Lower antibody production

    • Tetanus: GMTs (280)

Cytokine responses
  • Lower cytokine production

    • BCG: IL-2 (325)