TABLE 7

Results with regard to maternal infections from studies investigating perinatal factors that influence vaccine responses

Type of responseVaccine response and vaccine: measurement [reference(s)]
FilariasisHelminthsHookwormMalariaMansonella perstansSchistosomiasisStrongyloidiasisTrypanosoma cruzi
Humoral responses
  • Lower antibody production

    • Hib: GMTs (313)

  • No difference in antibody production

    • Diphtheria: GMTs (313)

    • HepB: GMTs (313)

    • Tetanus: GMTs (313)

  • Lower antibody production

    • Hib: GMTs (313)

  • No difference in antibody production

    • aP: GMTs (314)

    • Diphtheria: GMTs (313, 314)

    • HepB: GMTs (313, 314)

    • Hib: GMTs (314)

    • Tetanus: GMTs (313)

  • Lower antibody production

    • Hib: GMTs (313)

    • Measles: SPRs (318)

  • No difference in antibody production

    • Diphtheria: GMTs (313)

    • HepB: GMTs (313)

    • Tetanus: GMTs (313, 316)

  • No difference in antibody production

    • aP: GMTs (314)

    • Diphtheria: GMTs (314)

    • HepB: GMTs (314)

    • Hib: GMTs (314)

  • Lower antibody production

    • HepB: GMTs (317)

  • No difference in antibody production

    • aP: GMTs (314)

    • Diphtheria: GMTs (313, 314)

    • HepB: GMTs (313315)

    • Hib: GMTs (314)

    • Tetanus: GMTs (313)

  • Higher antibody production

    • Hib: GMTs (314)

    • HepB: GMTs (314)

    • PT: GMTs (314)

Cytokine responses
  • Lower cytokine production

    • BCG: IFN-γ (320)

  • No difference in cytokine production

    • BCG (319, 322, 323)

  • Higher cytokine production

    • BCG: IL-10 (319)

    • Tetanus: IL-10 (319)

  • Lower cytokine production

    • BCG: IL-5 (323)

  • Lower cytokine production

    • BCG: IFN-γ (320)

  • Lower cytokine production

    • BCG: IFN-γ (321)