TABLE 2

Published studies examining the relationship between Ureaplasma spp. and male infertility

Authors (yr)ReferenceCountry of studyPatient groupSample typeNo. of participantsMethod of identificationSpecies differentiatedKey findings relating to Ureaplasma spp.
Huang et al. (2016)57ChinaMen attending a reproductive centerSemen19,098 infertile men and 3,368 fertile menCultureNoUreaplasma spp. were significantly associated with infertility.
Ureaplasma spp. were significantly associated with reduced motility and normal forms in infertile men compared with fertile controls.
Huang et al. (2015)56Multiple countriesMeta-analysisNAa611 infertile men and 506 fertile menNAYesU. urealyticum was significantly associated with infertility.
U. parvum was not associated with infertility.
Zhang et al. (2014)54ChinaMen attending an infertility clinicSemen223 infertile men and 146 fertile menCultureYesU. urealyticum was significantly associated with infertility compared with U. parvum.
Semen positive for U. urealyticum showed a decreased concentration of spermatozoa and decreased motility.
Abusarah et al. (2013)55JordanMen attending a urology clinicSemen and first-void urine93 infertile men and 70 fertile menPCRYesUreaplasmas were found more frequently among samples from infertile men (10.8%) than among those from fertile men (5.7%).
Zeighami et al. (2009)53IranMen attending an infertility centerSemen100 infertile men and 100 fertile controlsPCRYesUreaplasmas were detected significantly more often in semen from infertile men than in semen from controls.
U. urealyticum was detected in 9% of infertile men vs 1% of control men.
U. parvum was detected in 3% of infertile men vs 2% of control men.
  • a NA, not applicable.