TABLE 1

Case definitions of CARV-RTIDa

Case definition
Case classification
  • Case types

    • Possible case: meeting the clinical criteria of RTID

    • Probable case: meeting the clinical criteria of RTID and having an epidemiological link

    • Presumptive case: meeting the clinical criteria of RTID and the laboratory criteria (laboratory confirmed)

    • Proven case: histological evidence of CARV pathology

Clinical criteria
  • New onset of 1 of the following systemic symptoms/signs in the previous 5 days

    • Fever

    • Feverishness

    • Myalgia

    • Nausea

    AND
  • At least 1 of the following 4 respiratory symptoms

    • Cough

    • Sore throat

    • Shortness of breath

    • Coryza

    AND
  • Clinician’s judgment that the illness is due to an infectious agent

Epidemiological criteria
  • An epidemiological link to human-to-human transmission, such as

    • CARV activity in the community

    • Contact with visitor, another patient, or healthcare worker

Laboratory criteria
  • Detection of CARV in a clinical specimen, preferably from the site of clinical involvement, by at least 1 of the following

    • Nucleic acid amplification testing (NAT)

    • Virus isolation by cell culture (VIC)

    • Direct virus antigen detection (DAD)

    AND
  • Exclusion of a major role of other etiologies (another infectious agent or disease)

  • a Modified from reference 5.