TABLE 4

Use of systemic ribavirin for RTID with HRSV, HPIV, and HMPVa

Treatment courseDescription
Oral or intravenous ribavirin maximal dosing at 10 mg/kg body weight every 8 h for adultsDay 1: start with 600 mg loading dose, then 200 mg every 8 h
Day 2: 400 mg every 8 h
Day 3: Increase the dose to a maximum of 10 mg/kg body weight every 8 h
In case of adverse events, decrease dose or discontinue ribavirin
Oral or intravenous administration according renal functionDose for a creatinine clearance of 30 to 50 ml/min: a maximum of 200 mg every 8 h
For a creatinine clearance of 10 to 30 ml/min, no dose recommendation can be givenb
  • a Modified from reference 5 on the basis of data from reference 73.

  • b Some experts use 200 mg once daily under close clinical and laboratory monitoring.