TABLE 2

Major diseases caused by B19V infection

Disease(s)ProgressionHost(s)
Erythema infectiosumAcuteHealthy children
ArthropathyAcute or chronicHealthy adults
Hydrops fetalis/fetal lossAcute or chronicFetus
Transient aplastic crisisAcutePatients with a high rate of red blood cell turnover, e.g., sickle cell disease patients
Persistent infection and pure red cell aplasiaChronicImmunocompromised patients, e.g., HIV/AIDS or postchemotherapy patients