TABLE 2

Protein interactions involved in progression and pathogenicity of staphylococcal infection

OrganismMSCRAMM(s)Matrix/bridge protein(s)ReceptoraFunctional responseReference(s)
S. aureusCollagen adhesion (CNA)CollagenNAColonization68, 201
Bone sialoprotein (Bbp)FibrinogenBone sialoproteinUnknown67, 202
Fibronectin binding proteins (FnBP)Fibronectinα5β1Internalization5860
Staphylococcal protein A (SpA)TNFR1Induction of bone loss (apoptosis) and bone destruction (osteoclastogenesis), inhibits mineralization5154
S. epidermidisSerine-aspartate repeat-containing proteins (Sdr)Fibrinogen, collagenNAColonization13, 78, 79, 82
Extracellular matrix binding protein (Embp)FibronectinNAColonization83, 203, 204
Autolysin E (AtlE)VitronectinNAColonization84
Autolysin adhesion protein (Aae)VitronectinNAColonization85
GehD lipaseCollagenNAColonization86, 205
  • a NA, not available.