TABLE 3

Synergistic activity of fosfomycin in combination with other antibiotics against several clinically relevant bacteria

Organism(s)Antibiotics with activity in combination with fosfomycin (reference[s])
SynergyIndifferenceAntagonism
MSSALinezolid (174), ciprofloxacin (24), ceftriaxone (137), ciprofloxacin (137), rifampin (137)Vancomycin (137), ceftriaxone (137), gentamicin (137)
MRSACefamandole (138, 139, 268), cefazolin (138, 139, 268), vancomycin (29, 137, 229), rifampin (29, 90, 142, 147), carbapenems (13, 152), cefmetazole (13), cefoperazone-sulbactam (13), linezolid (161), quinupistin-dalfopristin (162), fusidic acid (90), minocycline (163), tigecycline (29), daptomycin (29, 165)Aminoglycosides (268), fusidic acid (268), trimethoprim (268), vancomycin (137)Rifampin (139)
Glycopeptide-intermediate S. aureus Imipenem (166), vancomycin (166), linezolid (166)
CoNSCiprofloxacin (137), imipenem (137), rifampin (137)Vancomycin (137)
MR S. epidermidis Vancomycin (167)
Enterococcus Cefotaxime (137), daptomycin (137),a imipenem (137)a
VREDaptomycin (36), teicoplanin (92), amoxicillin (36), linezolid (36, 92),b ampicillin (92),b vancomycin (92),a tigecycline (92),a rifampin (92)a Nitrofurantoin (92), minocycline (92)Ampicillin (92)
Streptococcus spp.Penicillin (137),a cefminox (137),a cefotaxime (137)a Vancomycin (137), imipenem (137), ceftriaxone (137), cefepime (137)
E. coli Gentamicin (137)a
ESBL-producing E. coli Carbapenems (84),a aztreonam (153),colistin (84),b aminoglycosides (28, 84),a tigecycline (28, 84),a colistin (28)
ESBL-producing K. pneumoniae Carbapenems (84), colistin (84),b netilmicin (84),a tigecycline (84)a
K. pneumoniae Gentamicin (137)a
MDR K. pneumoniae Carbapenem (152), aztreonam (153)
CR K. pneumoniae Carbapenems (84, 164, 179), colistin (84, 164, 179),a tigecycline (84),a netilmicin (84)a Gentamicin (179)Colistin (156), (OXA-48-producing strain)
NDM-1-producing Enterobacteriaceae Colistin (158), tigecycline (158)
Salmonella Amilacin (137),a cefepime (137)
P. aeruginosa Aztreonam (137),a levofloxacin (137),a ciprofloxacin (137),a cefepime (137),a gentamicin (137),a piperacillin (137),a ceftazidime (137),a imipenem (137)a Imipenem (137), ceftazidime (137), ciprofloxacin (137), gentamicin (137)
CR P. aeruginosa Colistin (149),a carbapenems (149, 150),a aminoglycosides (27, 40), piperacillin-tazobactam (40), ceftazidime (40), cefepime (40), ciprofloxacin (40)
MDR P. aeruginosa Carbapenems (84), colistin (189),b tigecycline (84),b netilmicin (84)b Carbapenems (152), aminoglycosides (168)
Acinetobacter Amikacin (137)a Imipenem (137), ceftazidime (137), ciprofloxacin (137)
OXA-23-producing Acinetobacter Colistin (59, 89),a , b sulbactam (89)
Pan-drug-resistant Acinetobacter Polymyxin B (90),b minocycline (90)b
N. gonorrhoeae Ceftriaxone (44)Cefixime (159, 253), ceftriaxone (159, 253), azithromycin (253), colistin (253), ertapenem (253), gentamicin (253), minocycline (253), oxifloxacin (253)
  • a Synergy was observed in ≤50% of tested strains.

  • b Synergy was observed in <20% of tested strains.