TABLE 1

Examples of natural SCV-like phenotypes in nonstaphylococcal species

MicroorganismaReferencePhenotypic changesbSourceInfection or underlying diseaseCommentsc
Gram-positive organisms
    Bacillus licheniformis 217 Increased susceptibilities to cefuroxime and cefotaximeBlood cultureBacteremia due to pacemaker lead infectionParallel isolation of isogenic NP organisms from pacemaker leads
    Enterococcus faecalis 218 Decreased inhibition zone diameters with benzylpenicillinUmbilical exudateRecurrent omphalitisOleate dependent
    Enterococcus faecium 110 Reduced alpha-hemolysisBlood cultureSepsis in patient with acute myeloid leukemiaParallel isolation of isogenic NP organisms from blood
    Streptococcus tigurinus 219 Reduced alpha-hemolysis, increased resistance to induced autolysisBiopsy samples from periprosthetic tissueProsthetic joint infectionTotal knee arthroplasty with gentamicin-containing cement
Gram-negative organisms
    Burkholderia cepacia complex 220 Increased MICs of meropenem, cefotaxime, and trimethoprim-sulfamethoxazoleRespiratory tract specimensCystic fibrosisFound in 1.7% of CF patients over a 22-month period
    Enterobacter aerogenes 221 Increased MICs of aminoglycosidesBlood culturePhlebitis, sepsisPatient had received suboptimal gentamicin therapy
    Escherichia coli 222 Transparent coloniesUrineUrinary tract infectionsDeficiencies in cysteine, thiamine, thymidine, and/or glutamine
    Pseudomonas aeruginosa 223 Increased MICs of antipseudomonal agentsRespiratory tract specimensCystic fibrosisFound in 38.4% of P. aeruginosa-positive CF patients over a 2-yr period
  • a Restricted to publications since 1970.

  • b Changes in comparison to the normal phenotype; restricted to those beyond reduced growth and formation of colonies with a drastically reduced size.

  • c NP, normal phenotype.