TABLE 6

Clinical symptoms of Zika fever

Clinical symptom(s)Main characteristic(s) (reference)Location(s), % (mean duration [days]) of symptomsbReferences
Maculopapular rash/pruritisDiffuse maculopapular rash on palms and soles (Fig. 8); can be pruriginous or lacking (119)YS, 80-90 (6); FP, 93 (5.2) 14, 17, 27, 28, 127, 144, 145, 206, 211, 213, 214, 216, 217, 222, 230, 232 234, 241, 242, 247, 259 - 261, 265, 266, 307, 452, 453, 480
Fatigue/lethargy/asthenia FP, 78 14, 144, 232, 234, 241, 242, 259, 261, 453, 480
FeverUsually mild and mostly self-reportedd; abrupt onset of high fever very uncommon; high fever (around 39°C) reported in 2 Brazilian (28), 7 Indonesian (119), and 1 Colombian (451) patientsYS, 65-70; FP, 72 (2.9) 2, 14, 17, 27, 28, 119, 125, 127, 144, 145, 206, 213, 214, 216, 217, 221, 222, 230, 234, 241, 242, 247, 260, 265, 266, 303, 307, 336, 336, 349, 367, 450 - 452, 480
Arthritis/arthralgia/myalgiaMainly involves hands, feet, and knees; edema of extremities can be associatedYS, 60-65 (3-5); FP, 65 (6.8)e 14, 17, 27, 28, 119, 125, 144, 145, 206, 211, 214, 216, 217, 221, 230, 232 234, 247, 259, 260, 265, 303, 307, 336, 452, 453
ConjunctivitisLimited to a bilateral conjunctiva hyperemia (Fig. 8)YS, 55-65; FP, 63 (3.5) 17, 28, 119, 145, 211, 214, 221, 222, 230, 233, 234, 247, 259, 260, 265, 336, 452, 453
Headache YS, 40-45; FP, 46 2, 14, 17, 27, 28, 125, 127, 144, 145, 232, 242, 247, 259, 265, 303, 307, 336, 349, 367
Malaise 28, 119, 127, 213, 221, 234, 259, 367
Jaundice 2
Chills 119, 213, 232, 242, 303
Dizziness YS, 10 119
Joint pain/swelling/edema YS, 19-20; FP, 47 2, 17, 28, 145, 213, 214, 221, 222, 230, 232, 261, 452
Burning sensation in extremities 214
Retro-orbital pain YS, 30-39; FP, 16 7, 28, 145, 247, 266, 303
Anorexia 119, 336
Photophobia 232
Gastrointestinal disorders YS, 8-10; FP, 28 14, 28, 119, 144, 241, 261, 336
Sore throat FP, 23 214, 265, 336, 349
Cough 2, 259, 349
Rhinorrhea 265
Aphthous ulcer FP, 4 17, 232, 241, 242
Hypotension 119
Hematuria 119
Prostatitis 232
Back pain 127, 234, 242, 303
Hearing difficulties 214
Hematospermia 232
Lymphadenopathy FP, 15 28, 119, 145, 211, 221, 230, 303
Sweating 303
Laboratory abnormalities
    Albuminemia 2
    Increased transaminases 144, 217, 453
    Increased lactate dehydrogenase 452
    Bile pigment in urine 2
    ThrombocytopeniaNormal-to-low-normal platelet countc YS, FP 144, 145, 221, 222, 241, 242, 247, 307
    LeukopeniaNormal-to-low-normal leukocyte countc YS, FP 28, 144, 145, 206, 217, 221, 230, 247, 259
    Reactive lymphocytes 144, 145, 206, 221, 259, 452
    C-reactive proteinNormal to slightly increasedc FP 27, 211, 222