Table 3.

Susceptibilities of M. genitalium to various antibiotics compared with those of M. hominis and Ureaplasma spp. a

AntibioticSusceptibility of:
M. genitaliumM. hominisUreaplasma spp.
Tetracyclines
    Tetracycline±++
    Doxycycline±++
    Minocycline±++
Macrolides
    Erythromycin++
    Clarithromycin++±+++
    Azithromycin++++
Lincosamides
    Clindamycin±+++±
Quinolones
    Ciprofloxacin++±
    Ofloxacin±++
    Moxifloxacin++++++
Penicillins
Rifamycins
  • a +++, extremely sensitive (MIC ≤ 0.005 μg/ml); ++, highly sensitive (MIC ≤ 0.05 μg/ml); +, moderately sensitive (MIC ≤ 0.1 μg/ml); ±, weakly sensitive (MIC, 0.5 to 2 μg/ml); −, insensitive. Note that some strains of M. genitalium are resistant to macrolides and that some strains of M. hominis and Ureaplasma spp. are resistant to the tetracyclines (MICs of 2 to >64 μg/ml).