Table 3.

Critical concentrations for drug susceptibility testing of Mycobacterium tuberculosis in solid and liquid media a

DrugCritical concn (μg/ml)
7H10 solid mediumLJ solid mediumMGITVersaTREKMB/BacT AlertBactec 460
First line
    INH0.2, 10.20.1, 0.40.1, 0.41.00.1, 0.4
    RIF14011.01.02
    EMB5, 1025.0, 7.55, 82.52.5, 7.5
    PZANANA100NRNR100
    SM2, 1041, 4812, 6
Second line
    Amikacin4.0NR1.5NRNR1
    Capreomycin10402.5–3.0NRNR1.25
    Ciprofloxacin221NRNR2
    Ethionamide5405NRNR1.25
    Kanamycin530NRNRNR5
    Levofloxicin221.5–2.0NRNRNR
    Ofloxacin222NRNR2
    PAS b 21NRNRNR4
  • a See references 100, 111, 141, 168, 198, and 205. NA, PZA has not been validated for testing on solid media; NR, critical concentrations have not been established or reported.

  • b PAS, para-aminosalicylic acid.