Table 2

All-cause mortality for patients with Staphylococcus aureus bacteremia stratified by source of infectiona

DiagnosisIn-hospital mortality (%) (reference[s])28–30-day mortality (%) (reference[s])Description (reference[s])
Bacteremia without focus11–45 (14, 161, 167)21.9–47.5 (120, 206, 296, 301)14-day mortality rate, 49% (39); independent predictor of mortality relative to other infections in several studies, with an OR range between 3.88 and 12.3 (15, 39, 206, 301)
Bone and joint infection0–13.9 (14, 19, 76, 80, 167)0–29 (120, 296, 301)14-day mortality rate, 11.7% (296); mortality dependent on site, with higher rates for vertebral osteomyelitis than for nonvertebral infections; independent predictor of reduced mortality relative to other infections in a single study, with an OR of 0.27 (95% CI, 0.08–0.93; P = 0.038) (133)
Prosthetic joint infection8.3 (296)
CNS infection25–56 (14, 126, 223, 228)10.7 (296)Independent predictor of mortality relative to other infections in a single study, with an OR of 12.9 (95% CI, 1.1–152.9; P value not stated) (244)
Deep abscess14.6 (296)
Intra-abdominal infection25 (120)
Intravenous catheter (type not specified or several types)0–21 (14, 54, 113, 167, 169, 205, 235, 313)4–32.6 (120, 296, 301)14-day mortality rate, 12% (39); device with a metastatic infection associated with higher mortality rates (296); independent predictor of reduced mortality relative to other infections in a single study, with an OR of 0.47 (95% CI, 0.31–0.71; P < 0.01) (33)
Central venous catheter30 (291)20.5 (296)
Hickman catheter22 (53)
Peripheral venous catheter16.9 (296)
Hemodialysis catheter6.8 (296)
Infective endocarditis22.4–66 (8, 15, 66, 106, 107, 167, 237, 242, 291)25–60 (29, 107, 206, 301)IVDU-associated IE mortality rate, 11%; non-IVDU IE mortality rate of 21%, vs 29.4% for health care-associated IE (66); infection-related mortality rate, 22% (68); independent predictor of mortality relative to other infections in several studies, with an OR range between 2.8 and 12.1 (77, 168, 237, 296, 301)
Left-sided IE28.6 (197)23.9 (296)Aortic valve IE was an independent predictor of mortality relative to mitral or right-sided IE, with an OR of 1.91 (95% CI, 1.0–3.66; P = 0.05) (197)
Right-sided IE5.9 (197)11.8 (296)
Prosthetic valve IE30.5–50 (66, 242)
Cardiac device infection36.4 (28)
Pulmonary infection41.6–62 (14, 79, 167, 200)39–67 (120, 148, 296, 301)14-day mortality rate, 65% (39); attributable mortality rate, 46.5% (85); independent predictor of mortality relative to other infections in several studies, with an OR range of between 2.09 and 17.0 (33, 39, 41, 134, 206, 296, 301)
Skin and soft tissue infection10–18.6 (14, 167)14.8–17 (120, 296, 301)
Surgical site infection0–23 (14, 291)
Urinary tract infection9.7 (14)10 (120)
  • a For the purpose of this review, no attempt has been made to differentiate between the various study diagnosis definitions, with source of infection, primary focus, or principal diagnosis being used interchangeably.

  • OR, odds ratio; CI, confidence interval; IVDU, intravenous drug user.