Table 4

Clinical studies, antimicrobial therapies, and outcomes for patients infected with KPC-producing K. pneumoniae

ReferenceCountry (yr of publication)Study designNo. of patients with indicated infectionType of β-lactamase (no. of isolates)Treatment with active drug (no. of patients)Outcome (no. of successes/no. of failures)
252 Colombia (2006)Case reports23 (10 BSIs, 10 pneumonias, 1 endocarditis, 1 liver abscess, 1 empyema)KPC-2 (19)Carbapenem (4)3/1
153 USA (2006)KPC-3 (2)Colistin (3)2/1
257 China (2007)KPC-type enzyme (2)Tigecycline (1)0/1
71 USA (2007)Aminoglycoside (2)1/1
6 USA (2008)Tigecycline-colistin (2)1/1
162 China (2008)Tigecycline-aminoglycoside (1)1/0
81 USA (2008)Colistin-aminoglycoside (1)1/0
159 USA (2009)Aminoglycoside-fluoroquinolone (1)1/0
17 Israel (2009)Carbapenem-aminoglycoside (1)1/0
158 USA (2009)No active drug (7)1/6
80 USA (2009)
116 USA (2010)
138 Brazil (2011)
52 Taiwan (2011)
10 Switzerland (2011)
113 USA (2011)
25 USA (2004)Case series4 (1 BSI, 2 urinary tract infections [UTIs], 1 pneumonia)KPC-2 (4)Carbapenem (1)1/0
Carbapenem-colistin (1)1/0
Carbapenem-aminoglycoside (1)1/0
Colistin (1)0/1
258 USA (2009)Case series21 (5 pneumonias, 5 BSIs, 4 cases of tracheobronchitis, 5 UTIs, 1 case of meningitis, 1 surgical site infection [SSI])KPC-3 (21)Carbapenem (4)2/2
Tigecycline (5)4/1
Aminoglycoside (3)3/0
Carbapenem-tigecycline (1)0/1
Tigecycline-aminoglycoside (1)1/0
No active drug (7)3/4
154 Greece (2009)Case series13 (9 pneumonias, 4 BSIs)KPC-2 (13)Aminoglycoside (2)2/0
Tigecycline-colistin (8)6/2
Colistin-aminoglycoside (3)3/0
83 USA (2009)Case series7 (3 BSIs, 1 UTI, 3 urinary colonizations)KPC-2 (1)Colistin (1)0/1
KPC-3 (6)Colistin-aminoglycoside (2)0/2
No active drug (4)0/4
182 USA (2009)Case series3 BSIsKPC-2 (3)Tetracycline-aminoglycoside (1)1/0
Colistin (3)1/2
237 Greece (2010)Case series17 (11 BSIs, 2 SSIs, 1 UTI, 2 pneumonias, 1 case of cholangitis)KPC-2 (17)Colistin (11)6/5
Tigecycline (1)1/0
Aminoglycoside (1)1/0
Colistin-aminoglycoside (2)1/1
Tigecycline-colistin-aminoglycoside (1)1/0
No active drug (1)1/0
175 Greece (2010)Case-control study19 BSIsKPC-2 (19)Colistin (10)2/8
Colistin-aminoglycoside (9)4/5
274 Greece (2011)Case-control study53 BSIsKPC-2 (53)Carbapenem (1)0/1
Colistin (7)3/4
Tigecycline (5)3/2
Aminoglycoside (2)2/0
Colistin-aminoglycoside (2)2/0
Carbapenem-aminoglycoside (1)1/0
Tigecycline-colistin (9)9/0
Tigecycline-aminoglycoside (4)4/0
Carbapenem-tigecycline (1)1/0
Carbapenem-tigecycline-colistin (2)2/0
Tigecycline-colistin-aminoglycoside (1)1/0
No active drug (18)7/11