Table 8

Experimental β-lactamase inhibitors active against carbapenemases from Enterobacteriaceae

InhibitorCompound typeInhibition spectrum (β-lactamase classes)Susceptible carbapenemasesaReference(s)
BLI-489PenemA, C, DKPC type 209
J-110,411 and J-111,2251-β-Methyl carbapenemA, C, BIMP type 183, 184
Mercaptomethyl sulfonesC-6-substituted penicillin sulfoneBVIM and IMP types 38
2,3-(S,S)-Disubstituted succinic acidsSuccinic acidBIMP type 170
Thiomandelic acidsThiolBVIM and IMP types 147, 268
Avibactam (NLX104)Diazabicyclo-octanoneA, C, DKPC type 22
  • a Only carbapenemase types with documented susceptibility to the respective inhibitor are included.