Table 6

Summary of retrospective hospital-based studies of severe malaria a

Yr of publication (reference)LocationNo. of admissions No. of severe cases No. of fatal cases DiagnosticsDominant P. vivax syndromes
P. falciparumP. vivaxP. falciparumP. vivaxP. falciparumP. vivax
2001 (120)South Korea010102900MST, SR
2004 (121)Malaysia304386283101MNR
2007 (122)Indonesia3,9671,13533036799MSMA, CS, Jd
2007 (123)Pakistan242270230 (total for both species)54M, RST, SMA
2009 (124)India41221NR29NR3M, RST, HD, RD, ARDS
2009 (125)Venezuela1171711MSMA, Jd
2012 (126)BrazilNRNR52922MRD, SAM, MAc, SMA, CS
2012 (127)India105156354679MSMA, ST, CS, SAM, ARDS, MOD
2012 (128)Indonesia1,5411,8374001994618MSMA, CS, RD, Jd
2012 (129)Pakistan3739332611M, PSMA, CS, ST
  • a M, microscopy; R,rapid diagnostic test; P, PCR; ARDS, acute respiratory distress syndrome; CS, cerebral syndrome (coma or seizures); HD, hepatic dysfunction; Jd, jaundice; MAc, metabolic acidosis; MOD, multiple organ dysfunction; RD, renal dysfunction; SAM, shock or algid malaria; SMA, severe malarial anemia; SpM, splenomegaly; ST, severe thrombocytopenia; NR, not reported.