Table 1

Summary of FDA-approved seasonal influenza vaccines as of 2013a

Vaccine (yr licensed)ManufacturerComposition(s), delivery methodHA doseProduction sourceAge(s) of target population(s)Dose
Afluria (2007)CSL, AustraliaTrivalent, split virion, intramuscular45 μg (15 μg HA/strain)Egg5–8 yr (unprimed)Two 0.5-ml doses, 4 wk apart
5–8 yr (primed), ≥9 yr0.5-ml single dose
FluLaval (2006)ID Biomedical Corporation, Quebec, CanadaTrivalent, split virion, intramuscular45 μg (15 μg HA/strain)Egg≥18 yr0.5-ml single dose
Fluarix (2012)GlaxoSmithKline BiologicsQuadrivalent, split virion, intramuscular60 μg (15 μg HA/strain)Egg3–8 yr (unprimed)Two 0.5-ml doses, 4 wk apart
3–8 yr (primed), ≥9 yr0.5 ml single dose
Fluvirin (1998)Novartis Vaccines and Diagnostics, Inc.Trivalent, subunit, intramuscular45 μg (15 μg HA/strain)Egg4–8 yr (unprimed)Two 0.5-ml doses, 4 wk apart
4–8 yr (primed), ≥9 yr0.5-ml single dose
Agriflu (2009)Novartis Vaccines and Diagnostics, Inc.Trivalent, subunit, intramuscular45 μg (15 μg HA/strain)Egg≥18 yr0.5-ml single dose
Flucelvax (2012)Novartis Vaccines and Diagnostics, Inc.Trivalent, subunit, intramuscular45 μg (15 μg HA/strain)MDCK cell derived≥18 yr0.5-ml single dose
Fluzone (1980)Sanofi Pasteur, Inc.Trivalent, split virion, intramuscular45 μg (15 μg HA/strain)Egg6 mo–3 yr (unprimed)Two 0.25-ml doses, 4 wk apart
6 mo–3 yr (primed)0.25-ml single dose
3–8 yr (unprimed)Two 0.5-ml doses, 4 wk apart
3–8 yr (primed), ≥9 yr0.5-ml single dose
Fluzone High-Dose (2009)Sanofi Pasteur, Inc.Trivalent, split virion, intramuscular180 μg (60 μg HA/strain)Egg≥65 yr0.5-ml single dose
Fluzone-Intradermal (2011)Sanofi Pasteur, Inc.Trivalent, split virion, intradermal27 μg (9 μg HA/strain)Egg18–64 yr0.1-ml single dose
FluBlok (2013)Protein SciencesTrivalent, intramuscular135 μg eachExpresSF+ (proprietary insect cells) using baculovirus expression system18–49 yr0.5-ml single dose
FluMist (2003)MedImmuneLive attenuated, trivalent, intranasal106.5-107.5 FFUb virus/strainEgg2–8 yr (unprimed)Two 0.2-ml doses, 4 wk apart
2–8 yr, (primed) 9–49 yr0.2-ml single dose
FluMist Quadrivalent (2012)MedImmuneLive attenuated, quadrivalent, intranasal106.5-107.5 FFU virus/strainEgg2–8 yr (unprimed)Two 0.2-ml doses, 4 wk apart
2–8 yr (primed), 9–49 yr0.2-ml single dose