Table 2

Daptomycin cure rate of MRSA infections by daptomycin MIC a

Daptomycin MIC, μg/ml b Cure, n c Total, n d Cure rate, % (95% CI) e References
≤137643486.6 (83.4–89.8) 11, 12, 73, 202 217
2153148.4 (30.8–66.0) 12, 98, 202, 216 222
431421.4 (0.0–42.9) 12, 216, 217 223, 224
≥8020 76, 77
  • a MRSA, methicillin-resistant Staphylococcus aureus.

  • b MIC by broth microdilution, Etest, or automated method. The isolate with the highest MIC was included. Etest results were rounded up to the nearest dilutional integer for comparison.

  • c Microbiological or clinical cure. Where both were presented in a relevant study, the lower cure rate was chosen for a more conservative estimate.

  • d Data pooled from multiple studies and case reports, with additional data clarification by the study authors where possible. See Table S1 in the supplemental material for further details.

  • e 95% CI, 95% confidence interval.