Table 3

Daptomycin cure rate of VRE infections by daptomycin MIC a

Daptomycin MIC, μg/ml b Cure, n c Total, n d Cure rate, % (95% CI) e References
≤16785.7 (60.6–100) 79, 225 227
2121963.2 (37.5–88.9) 79, 225, 228 231
4334475.0 (52.3–97.7) 79, 225, 230 233
≥8050.0 75, 160, 183, 234, 235
  • a VRE, vancomycin-resistant Enterococcus, including E. faecalis, E. faecium, E. raffinosus, and E. gallinarum.

  • b MIC by broth microdilution, Etest, or automated method. The isolate with the highest MIC was included. Etest results were rounded up to nearest dilutional integer for comparison.

  • c Microbiological or clinical cure. Where both were presented in a relevant study, the lower cure rate was chosen for a more conservative estimate.

  • d Data pooled from multiple studies and case reports, with additional data clarification by study authors where possible. See Table S2 in the supplemental material for further details.

  • e 95% CI, 95% confidence interval.