Table 1

General overview of enteric E. coli pathotypes

PathotypeHost(s)Site of colonizationDisease(s)Known reservoir(s)/source(s) of contaminationTreatmentAdhesion a Genetic identifiers
tEPECChildren <5 yr, adults at high inoculaSmall intestineProfuse watery diarrheaHumansOral rehydration, antibiotics for persistent casesAttaching and effacing eae +, bfp +, stx
aEPECHumans, animals eae +, stx
STECAdults, childrenDistal ileum, colonWatery diarrhea, hemorrhagic colitis, HUSHumans, animals, food, waterHydration, supportive for HUSAttaching and effacing b eae +/−, stx +
EIEC/Shigella Children <5 yr, adults, travelers, immunocompromised personsColonShigellosis/bacillary dysentery, potential HUSHumans, animals, food, waterOral rehydration, antibioticsNA (invasive) ipaH +, ial +, stx+ (S. dysenteriae)
EAECAdultsSmall intestine and/or colonTraveler's diarrhea, HUS (stx +)Food, occasionally adult carriersAntibiotics, oral rehydrationStacked brick and/or invasive aatA+ , aaiC+ (535), other candidates (585)
ChildrenPersistent diarrheaAntibiotics, oral rehydration, potentially probiotics
Immunocompromised personsPersistent diarrheaFluoroquinolones (685)
ETECChildren <5 yr, travelersSmall intestineWatery diarrheaFood, water, humans, animalsRehydration, antibioticsCF mediatedCFs, LT, ST
DAECChildren (increasing in severity from 18 mo to 5 yr), adultsIntestine (uncharacterized location)Persistent watery diarrhea in children, speculated to contribute to Crohn's disease in adults (809)UnknownRehydrationDiffuse adherent and/or invasiveNo uniform markers (802)
AIECAdults, childrenSmall intestineCrohn's diseaseUnknownAntibiotics, surgical resectionNA (invasive)Uncharacterized
  • NA, not applicable.

  • b Only for LEE-positive STEC, not for LEE-negative STEC.