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Antiviral Agents

  • Understanding the Impact of Resistance to Influenza Antivirals
    Review
    Understanding the Impact of Resistance to Influenza Antivirals

    Influenza poses a significant burden on society and health care systems. Although antivirals are an integral tool in effective influenza management, the potential for the emergence of antiviral-resistant viruses can lead to uncertainty and hesitation among front-line prescribers and policy makers.

    Edward C. Holmes, Aeron C. Hurt, Zuzana Dobbie, Barry Clinch, John S. Oxford, Pedro A. Piedra
  • Progress and Challenges in the Prevention, Diagnosis, and Management of Cytomegalovirus Infection in Transplantation
    Review
    Progress and Challenges in the Prevention, Diagnosis, and Management of Cytomegalovirus Infection in Transplantation

    Hosts with compromised or naive immune systems, such as individuals living with HIV/AIDS, transplant recipients, and fetuses, are at the highest risk for complications from cytomegalovirus (CMV) infection. Despite substantial progress in prevention, diagnostics, and treatment, CMV continues to negatively impact both solid-organ transplant (SOT) and hematologic cell transplant (HCT) recipients. In this article, we summarize important...

    Ajit P. Limaye, Tara M. Babu, Michael Boeckh
  • Host-Directed Antiviral Therapy
    Review
    Host-Directed Antiviral Therapy

    Antiviral drugs have traditionally been developed by directly targeting essential viral components. However, this strategy often fails due to the rapid generation of drug-resistant viruses. Recent genome-wide approaches, such as those employing small interfering RNA (siRNA) or clustered regularly interspaced short palindromic repeats (CRISPR) or those using small molecule chemical inhibitors targeting the cellular “kinome,” have been...

    Naveen Kumar, Shalini Sharma, Ram Kumar, Bhupendra N. Tripathi, Sanjay Barua, Hinh Ly, Barry T. Rouse
  • Review
    Clinical Laboratory Testing in the Era of Directly Acting Antiviral Therapies for Hepatitis C
    Eleanor M. Wilson, Elana S. Rosenthal, Sarah Kattakuzhy, Lydia Tang, Shyam Kottilil
  • Review
    Antiviral Drug Resistance of Human Cytomegalovirus
    Nell S. Lurain, Sunwen Chou
  • Review
    Respiratory Viruses Other than Influenza Virus: Impact and Therapeutic Advances
    W. Garrett Nichols, Angela J. Peck Campbell, Michael Boeckh
  • Review
    Viral Determinants of Resistance to Treatment in Patients with Hepatitis C
    Anette Wohnsland, Wolf Peter Hofmann, Christoph Sarrazin
  • Review
    Peptide Antimicrobial Agents
    Håvard Jenssen, Pamela Hamill, Robert E. W. Hancock
  • Review
    Update on Human Herpesvirus 6 Biology, Clinical Features, and Therapy
    Leen De Bolle, Lieve Naesens, Erik De Clercq
  • Review
    Herpes Simplex Virus Resistance to Acyclovir and Penciclovir after Two Decades of Antiviral Therapy
    Teresa H. Bacon, Myron J. Levin, Jeffry J. Leary, Robert T. Sarisky, David Sutton

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