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Clinical Microbiology Reviews
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clinical trials

  • Progress and Challenges in the Prevention, Diagnosis, and Management of Cytomegalovirus Infection in Transplantation
    Review
    Progress and Challenges in the Prevention, Diagnosis, and Management of Cytomegalovirus Infection in Transplantation

    Hosts with compromised or naive immune systems, such as individuals living with HIV/AIDS, transplant recipients, and fetuses, are at the highest risk for complications from cytomegalovirus (CMV) infection. Despite substantial progress in prevention, diagnostics, and treatment, CMV continues to negatively impact both solid-organ transplant (SOT) and hematologic cell transplant (HCT) recipients. In this article, we summarize important...

    Ajit P. Limaye, Tara M. Babu, Michael Boeckh
  • Tuberculosis Vaccine Development: Progress in Clinical Evaluation
    Review
    Tuberculosis Vaccine Development: Progress in Clinical Evaluation

    Tuberculosis (TB) is the leading killer among all infectious diseases worldwide despite extensive use of the Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccine. A safer and more effective vaccine than BCG is urgently required. More than a dozen TB vaccine candidates are under active evaluation in clinical trials aimed to prevent infection, disease, and...

    Suraj B. Sable, James E. Posey, Thomas J. Scriba
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