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Clinical Microbiology Reviews
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diagnostics

  • Laboratory Diagnosis of Lyme Borreliosis
    Review
    Laboratory Diagnosis of Lyme Borreliosis

    Lyme borreliosis is caused by a growing list of related, yet distinct, spirochetes with complex biology and sophisticated immune evasion mechanisms.

    John A. Branda, Allen C. Steere
  • Progress and Challenges in the Prevention, Diagnosis, and Management of Cytomegalovirus Infection in Transplantation
    Review
    Progress and Challenges in the Prevention, Diagnosis, and Management of Cytomegalovirus Infection in Transplantation

    Hosts with compromised or naive immune systems, such as individuals living with HIV/AIDS, transplant recipients, and fetuses, are at the highest risk for complications from cytomegalovirus (CMV) infection. Despite substantial progress in prevention, diagnostics, and treatment, CMV continues to negatively impact both solid-organ transplant (SOT) and hematologic cell transplant (HCT) recipients. In this article, we summarize important...

    Ajit P. Limaye, Tara M. Babu, Michael Boeckh
  • Beyond Cytomegalovirus and Epstein-Barr Virus: a Review of Viruses Composing the Blood Virome of Solid Organ Transplant and Hematopoietic Stem Cell Transplant Recipients
    Review
    Beyond Cytomegalovirus and Epstein-Barr Virus: a Review of Viruses Composing the Blood Virome of Solid Organ Transplant and Hematopoietic Stem Cell Transplant Recipients

    Viral primary infections and reactivations are common complications in patients after solid organ transplantation (SOT) and hematopoietic stem cell transplantation (HSCT) and are associated with high morbidity and mortality. Among these patients, viral infections are frequently associated with viremia. Beyond the usual well-known viruses that are part of the routine clinical management of transplant recipients, numerous other viral...

    Marie-Céline Zanella, Samuel Cordey, Laurent Kaiser
  • Performance of Zika Assays in the Context of <span class="named-content genus-species" id="named-content-1">Toxoplasma gondii</span>, Parvovirus B19, Rubella Virus, and Cytomegalovirus (TORCH) Diagnostic Assays
    Review
    Performance of Zika Assays in the Context of Toxoplasma gondii, Parvovirus B19, Rubella Virus, and Cytomegalovirus (TORCH) Diagnostic Assays

    Infections during pregnancy that may cause congenital abnormalities have been recognized for decades, but their diagnosis is challenging. This was again illustrated with the emergence of Zika virus (ZIKV), highlighting the inherent difficulties in estimating the extent of pre- and postnatal ZIKV complications because of the difficulties in establishing definitive diagnoses.

    Bettie Voordouw, Barry Rockx, Thomas Jaenisch, Pieter Fraaij, Philippe Mayaud, Ann Vossen, Marion Koopmans
  • Review
    The Cost-Effectiveness of Rapid Diagnostic Testing for the Diagnosis of Bloodstream Infections with or without Antimicrobial Stewardship
    Elina Eleftheria Pliakos, Nikolaos Andreatos, Fadi Shehadeh, Panayiotis D. Ziakas, Eleftherios Mylonakis
  • Review
    Molecular Tools for the Detection and Deduction of Azole Antifungal Drug Resistance Phenotypes in Aspergillus Species
    Anna Dudakova, Birgit Spiess, Marut Tangwattanachuleeporn, Christoph Sasse, Dieter Buchheidt, Michael Weig, Uwe Groß, Oliver Bader
  • Review
    Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment
    Cameron Griffiths, Steven J. Drews, David J. Marchant
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