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Clinical Microbiology Reviews
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Latest Articles

  • Free
    Viral Respiratory Pathogens and Lung Injury
    Review
    Viral Respiratory Pathogens and Lung Injury

    Several viruses target the human respiratory tract, causing different clinical manifestations spanning from mild upper airway involvement to life-threatening acute respiratory distress syndrome (ARDS). As dramatically evident in the ongoing SARS-CoV-2 pandemic, the clinical picture is not always easily predictable due to the combined effect of direct viral and indirect patient-specific immune-mediated damage.

    Nicola Clementi, Sreya Ghosh, Maria De Santis, Matteo Castelli, Elena Criscuolo, Ivan Zanoni, Massimo Clementi, Nicasio Mancini
    31 Mar 2021
  • Pathogenesis of Gram-Negative Bacteremia
    Review
    Pathogenesis of Gram-Negative Bacteremia

    Gram-negative bacteremia is a devastating public health threat, with high mortality in vulnerable populations and significant costs to the global economy. Concerningly, rates of both Gram-negative bacteremia and antimicrobial resistance in these species are increasing.

    Caitlyn L. Holmes, Mark T. Anderson, Harry L. T. Mobley, Michael A. Bachman
    10 Mar 2021
  • The Changing Face of the Family <em>Enterobacteriaceae</em> (Order: “<em>Enterobacterales</em>”): New Members, Taxonomic Issues, Geographic Expansion, and New Diseases and Disease Syndromes
    Review
    The Changing Face of the Family Enterobacteriaceae (Order: “Enterobacterales”): New Members, Taxonomic Issues, Geographic Expansion, and New Diseases and Disease Syndromes

    The family Enterobacteriaceae has undergone significant morphogenetic changes in its more than 85-year history, particularly during the past 2 decades (2000 to 2020). The development and introduction of new and novel molecular methods coupled with innovative laboratory techniques have led to many advances.

    J. Michael Janda, Sharon L. Abbott
    24 Feb 2021
  • Molecular Epidemiology of Human Cryptosporidiosis in Low- and Middle-Income Countries
    Review
    Molecular Epidemiology of Human Cryptosporidiosis in Low- and Middle-Income Countries

    Cryptosporidiosis is one of the most important causes for moderate to severe diarrhea and diarrhea-related mortality in children under 2 years in low- and middle-income countries. In recent decades, genotyping and subtyping tools have been used in epidemiological studies of human cryptosporidiosis.

    Xin Yang, Yaqiong Guo, Lihua Xiao, Yaoyu Feng
    24 Feb 2021
  • Understanding the Impact of Resistance to Influenza Antivirals
    Review
    Understanding the Impact of Resistance to Influenza Antivirals

    Influenza poses a significant burden on society and health care systems. Although antivirals are an integral tool in effective influenza management, the potential for the emergence of antiviral-resistant viruses can lead to uncertainty and hesitation among front-line prescribers and policy makers.

    Edward C. Holmes, Aeron C. Hurt, Zuzana Dobbie, Barry Clinch, John S. Oxford, Pedro A. Piedra
    10 Feb 2021
  • <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> in Agriculture: Lessons in Evolution from a Multispecies Pathogen
    Review
    Staphylococcus aureus in Agriculture: Lessons in Evolution from a Multispecies Pathogen

    Staphylococcus aureus is a formidable bacterial pathogen that is responsible for infections in humans and various species of wild, companion, and agricultural animals. The ability of S. aureus to move between humans and livestock is due to specific characteristics of this bacterium as well as modern...

    Soyoun Park, Jennifer Ronholm
    10 Feb 2021
  • Laboratory Diagnosis of Lyme Borreliosis
    Review
    Laboratory Diagnosis of Lyme Borreliosis

    Lyme borreliosis is caused by a growing list of related, yet distinct, spirochetes with complex biology and sophisticated immune evasion mechanisms.

    John A. Branda, Allen C. Steere
    27 Jan 2021
  • Free
    Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): a Systemic Infection
    Review
    Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): a Systemic Infection

    To date, seven identified coronaviruses (CoVs) have been found to infect humans; of these, three highly pathogenic variants have emerged in the 21st century. The newest member of this group, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first detected at the end of 2019 in Hubei province, China.

    Aleksandra Synowiec, Artur Szczepański, Emilia Barreto-Duran, Laurensius Kevin Lie, Krzysztof Pyrc
    13 Jan 2021
  • Type I Natural Killer T Cells as Key Regulators of the Immune Response to Infectious Diseases
    Review
    Type I Natural Killer T Cells as Key Regulators of the Immune Response to Infectious Diseases

    The immune system must work in an orchestrated way to achieve an optimal response upon detection of antigens. The cells comprising the immune response are traditionally divided into two major subsets, innate and adaptive, with particular characteristics for each type. Type I natural killer T (iNKT) cells are defined as innate-like T cells sharing features with both traditional adaptive and innate cells, such as the expression of an...

    Nicolás M. S. Gálvez, Karen Bohmwald, Gaspar A. Pacheco, Catalina A. Andrade, Leandro J. Carreño, Alexis M. Kalergis
    23 Dec 2020
  • <span class="named-content genus-species" id="named-content-1">Staphylococcus lugdunensis</span>: a Skin Commensal with Invasive Pathogenic Potential
    Review
    Staphylococcus lugdunensis: a Skin Commensal with Invasive Pathogenic Potential

    Staphylococcus lugdunensis is a species of coagulase-negative staphylococcus (CoNS) that causes serious infections in humans akin to those of S. aureus. It was often misidentified as S. aureus, but this has been rectified by...

    Simon Heilbronner, Timothy J. Foster
    23 Dec 2020

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About CMR

Clinical Microbiology Reviews ® (CMR) analyzes the latest developments in clinical microbiology and immunology, providing the current state of knowledge in the field, as well as balanced, thought-provoking perspectives on controversial issues.

Cumitechs & Practical Guidance for Clinical Microbiology.

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