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Clinical Microbiology Reviews
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Latest Articles

  • Beyond Cytomegalovirus and Epstein-Barr Virus: a Review of Viruses Composing the Blood Virome of Solid Organ Transplant and Hematopoietic Stem Cell Transplant Recipients
    Review
    Beyond Cytomegalovirus and Epstein-Barr Virus: a Review of Viruses Composing the Blood Virome of Solid Organ Transplant and Hematopoietic Stem Cell Transplant Recipients

    Viral primary infections and reactivations are common complications in patients after solid organ transplantation (SOT) and hematopoietic stem cell transplantation (HSCT) and are associated with high morbidity and mortality. Among these patients, viral infections are frequently associated with viremia. Beyond the usual well-known viruses that are part of the routine clinical management of transplant recipients, numerous other viral...

    Marie-Céline Zanella, Samuel Cordey, Laurent Kaiser
    26 Aug 2020
  • Free
    Convalescent Plasma Therapy for COVID-19: State of the Art
    Review
    Convalescent Plasma Therapy for COVID-19: State of the Art

    Convalescent plasma (CP) therapy has been used since the early 1900s to treat emerging infectious diseases; its efficacy was later associated with the evidence that polyclonal neutralizing antibodies can reduce the duration of viremia. Recent large outbreaks of viral diseases for which effective antivirals or vaccines are still lacking has renewed the interest in CP as a life-saving treatment. The ongoing COVID-19 pandemic has led to...

    Daniele Focosi, Arthur O. Anderson, Julian W. Tang, Marco Tuccori
    12 Aug 2020
  • Free
    The ASM Journals Committee Values the Contributions of Black Microbiologists
    Editorial
    The ASM Journals Committee Values the Contributions of Black Microbiologists
    Patrick D. Schloss, Melissa Junior, Rebecca Alvania, Cesar A. Arias, Andreas Baumler, Arturo Casadevall, Corrella Detweiler, Harold Drake, Jack Gilbert, Michael J. Imperiale, Susan Lovett, Stanley Maloy, Alexander J. McAdam, Irene L. G. Newton, Michael J. Sadowsky, Rozanne M. Sandri-Goldin, Thomas J. Silhavy, Peter Tontonoz, Jo-Anne H. Young, Craig E. Cameron, Isaac Cann, A. Oveta Fuller, Ariangela J. Kozik
    31 Jul 2020
  • The Echo of Pulmonary Tuberculosis: Mechanisms of Clinical Symptoms and Other Disease-Induced Systemic Complications
    Review
    The Echo of Pulmonary Tuberculosis: Mechanisms of Clinical Symptoms and Other Disease-Induced Systemic Complications

    Clinical symptoms of active tuberculosis (TB) can range from a simple cough to more severe reactions, such as irreversible lung damage and, eventually, death, depending on disease progression. In addition to its clinical presentation, TB has been associated with several other disease-induced systemic complications, such as hyponatremia and glucose intolerance. Here, we provide an overview of the known, although ill-described, underlying...

    Laneke Luies, Ilse du Preez
    1 Jul 2020
  • Free
    Coronavirus Disease 2019–COVID-19
    Review
    Coronavirus Disease 2019–COVID-19

    In recent decades, several new diseases have emerged in different geographical areas, with pathogens including Ebola virus, Zika virus, Nipah virus, and coronaviruses (CoVs). Recently, a new type of viral infection emerged in Wuhan City, China, and initial genomic sequencing data of this virus do not match with previously sequenced CoVs, suggesting a novel CoV strain (2019-nCoV), which has now been termed severe acute respiratory...

    Kuldeep Dhama, Sharun Khan, Ruchi Tiwari, Shubhankar Sircar, Sudipta Bhat, Yashpal Singh Malik, Karam Pal Singh, Wanpen Chaicumpa, D. Katterine Bonilla-Aldana, Alfonso J. Rodriguez-Morales
    24 Jun 2020
  • Antimicrobial Resistance Surveillance in Low- and Middle-Income Countries: Progress and Challenges in Eight South Asian and Southeast Asian Countries
    Review
    Antimicrobial Resistance Surveillance in Low- and Middle-Income Countries: Progress and Challenges in Eight South Asian and Southeast Asian Countries

    Antimicrobial resistance (AMR) is a serious global health threat and is predicted to cause significant health and economic impacts, particularly in low- and middle-income countries (LMICs). AMR surveillance is critical in LMICs due to high burden of bacterial infections; however, conducting AMR surveillance in resource-limited settings is constrained by poorly functioning health systems, scarce financial resources, and lack of skilled...

    Sumanth Gandra, Gerardo Alvarez-Uria, Paul Turner, Jyoti Joshi, Direk Limmathurotsakul, H. Rogier van Doorn
    10 Jun 2020
  • Infectious Complications of Biological and Small Molecule Targeted Immunomodulatory Therapies
    Review
    Infectious Complications of Biological and Small Molecule Targeted Immunomodulatory Therapies

    The past 2 decades have seen a revolution in our approach to therapeutic immunosuppression. We have moved from relying on broadly active traditional medications, such as prednisolone or methotrexate, toward more specific agents that often target a single receptor, cytokine, or cell type, using monoclonal antibodies, fusion proteins, or targeted small molecules. This change has transformed the treatment of many conditions, including...

    Joshua S. Davis, David Ferreira, Emma Paige, Craig Gedye, Michael Boyle
    10 Jun 2020
  • <span class="named-content genus-species" id="named-content-1">Taenia solium</span> Cysticercosis and Its Impact in Neurological Disease
    Review
    Taenia solium Cysticercosis and Its Impact in Neurological Disease

    Taenia solium neurocysticercosis (NCC) is endemic in most of the world and contributes significantly to the burden of epilepsy and other neurological morbidity. Also present in developed countries because of immigration and travel, NCC is one of few diseases targeted for eradication. This paper reviews all aspects of its life cycle (taeniasis, porcine cysticercosis,...

    Hector H. Garcia, Armando E. Gonzalez, Robert H. Gilman
    and for the Cysticercosis Working Group in Peru
    27 May 2020
  • Device-Associated Menstrual Toxic Shock Syndrome
    Review
    Device-Associated Menstrual Toxic Shock Syndrome

    In the 1980s, menstrual toxic shock syndrome (mTSS) became a household topic, particularly among mothers and their daughters. The research performed at the time, and for the first time, exposed the American public as well as the biomedical community, in a major way, to understanding disease progression and investigation. Those studies led to the identification of the cause, ...

    Patrick M. Schlievert, Catherine C. Davis
    27 May 2020
  • Antimicrobial Resistance in ESKAPE Pathogens
    Review
    Antimicrobial Resistance in ESKAPE Pathogens

    Antimicrobial-resistant ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae,...

    David M. P. De Oliveira, Brian M. Forde, Timothy J. Kidd, Patrick N. A. Harris, Mark A. Schembri, Scott A. Beatson, David L. Paterson, Mark J. Walker
    13 May 2020

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Clinical Microbiology Reviews ® (CMR) analyzes the latest developments in clinical microbiology and immunology, providing the current state of knowledge in the field, as well as balanced, thought-provoking perspectives on controversial issues.

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