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Clinical Microbiology Reviews
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Latest Articles

  • Tuberculosis Vaccine Development: Progress in Clinical Evaluation
    Review
    Tuberculosis Vaccine Development: Progress in Clinical Evaluation

    Tuberculosis (TB) is the leading killer among all infectious diseases worldwide despite extensive use of the Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccine. A safer and more effective vaccine than BCG is urgently required. More than a dozen TB vaccine candidates are under active evaluation in clinical trials aimed to prevent infection, disease, and...

    Suraj B. Sable, James E. Posey, Thomas J. Scriba
    30 Oct 2019
  • Practical Guidance for Clinical Microbiology Laboratories: A Comprehensive Update on the Problem of Blood Culture Contamination and a Discussion of Methods for Addressing the Problem
    Practical Guidance for Clinical Microbiology
    Practical Guidance for Clinical Microbiology Laboratories: A Comprehensive Update on the Problem of Blood Culture Contamination and a Discussion of Methods for Addressing the Problem

    In this review, we present a comprehensive discussion of matters related to the problem of blood culture contamination. Issues addressed include the scope and magnitude of the problem, the bacteria most often recognized as contaminants, the impact of blood culture contamination on clinical microbiology laboratory function, the economic and clinical ramifications of contamination, and, perhaps most importantly, a systematic discussion...

    Gary V. Doern, Karen C. Carroll, Daniel J. Diekema, Kevin W. Garey, Mark E. Rupp, Melvin P. Weinstein, Daniel J. Sexton
    30 Oct 2019
  • Early Events in Coccidioidomycosis
    Review
    Early Events in Coccidioidomycosis

    Since its description nearly 130 years ago, hundreds of studies have deepened our understanding of coccidioidomycosis, also known as valley fever (VF), and provided useful diagnostic tests and treatments for the disease caused by the dimorphic fungi Coccidioides spp. In general, most of the literature has addressed well-established infections and has described patients who have experienced major complications.

    ...
    Fariba M. Donovan, Lisa Shubitz, Daniel Powell, Marc Orbach, Jeffrey Frelinger, John N. Galgiani
    16 Oct 2019
  • Rapid Growth and Metabolism of Uropathogenic <span class="named-content genus-species" id="named-content-1">Escherichia coli</span> in Relation to Urine Composition
    Review
    Rapid Growth and Metabolism of Uropathogenic Escherichia coli in Relation to Urine Composition

    Uropathogenic Escherichia coli (UPEC) strains cause a majority of urinary tract infections (UTIs). Since UPEC strains can become antibiotic resistant, adjunct or alternate therapies are urgently needed. UPEC strains grow extremely rapidly in patients with UTIs. Thus, this review focuses on the relation between urine composition and UPEC growth and metabolism.

    ...
    Larry Reitzer, Philippe Zimmern
    16 Oct 2019
  • Community-Acquired Respiratory Viruses in Transplant Patients: Diversity, Impact, Unmet Clinical Needs
    Review
    Community-Acquired Respiratory Viruses in Transplant Patients: Diversity, Impact, Unmet Clinical Needs

    Patients undergoing solid-organ transplantation (SOT) or allogeneic hematopoietic cell transplantation (HCT) are at increased risk for infectious complications. Community-acquired respiratory viruses (CARVs) pose a particular challenge due to the frequent exposure pre-, peri-, and posttransplantation.

    Michael G. Ison, Hans H. Hirsch
    11 Sep 2019
  • Epidemiology and Treatment of Multidrug-Resistant and Extensively Drug-Resistant <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> Infections
    Review
    Epidemiology and Treatment of Multidrug-Resistant and Extensively Drug-Resistant Pseudomonas aeruginosa Infections

    In recent years, the worldwide spread of the so-called high-risk clones of multidrug-resistant or extensively drug-resistant (MDR/XDR) Pseudomonas aeruginosa has become a public health threat. This article reviews their mechanisms of resistance, epidemiology, and clinical impact and current and upcoming therapeutic options. In vitro and in vivo...

    Juan P. Horcajada, Milagro Montero, Antonio Oliver, Luisa Sorlí, Sònia Luque, Silvia Gómez-Zorrilla, Natividad Benito, Santiago Grau
    28 Aug 2019
  • The Use of Copper as an Antimicrobial Agent in Health Care, Including Obstetrics and Gynecology
    Review
    The Use of Copper as an Antimicrobial Agent in Health Care, Including Obstetrics and Gynecology

    Health care-associated infections (HAIs) are a global problem associated with significant morbidity and mortality. Controlling the spread of antimicrobial-resistant bacteria is a major public health challenge, and antimicrobial resistance has become one of the most important global problems in current times.

    Linda P. Arendsen, Ranee Thakar, Abdul H. Sultan
    14 Aug 2019
  • Transferable Mechanisms of Quinolone Resistance from 1998 Onward
    Review
    Transferable Mechanisms of Quinolone Resistance from 1998 Onward

    While the description of resistance to quinolones is almost as old as these antimicrobial agents themselves, transferable mechanisms of quinolone resistance (TMQR) remained absent from the scenario for more than 36 years, appearing first as sporadic events and afterward as epidemics. In 1998, the first TMQR was soundly described, that is, QnrA.

    Joaquim Ruiz
    14 Aug 2019
  • Consumer Safety Considerations of Skin and Oral Microbiome Perturbation
    Review
    Consumer Safety Considerations of Skin and Oral Microbiome Perturbation

    Microbiomes associated with human skin and the oral cavity are uniquely exposed to personal care regimes. Changes in the composition and activities of the microbial communities in these environments can be utilized to promote consumer health benefits, for example, by reducing the numbers, composition, or activities of microbes implicated in conditions such as acne, axillary odor, dandruff, and oral diseases.

    Andrew J. McBain, Catherine A. O’Neill, Alejandro Amezquita, Laura J. Price, Karoline Faust, Adrian Tett, Nicola Segata, Jonathan R. Swann, Adrian M. Smith, Barry Murphy, Michael Hoptroff, Gordon James, Yugandhar Reddy, Anindya Dasgupta, Tom Ross, Iain L. Chapple, William G. Wade, Judith Fernandez-Piquer
    31 Jul 2019
  • Organization of the Skin Immune System and Compartmentalized Immune Responses in Infectious Diseases
    Review
    Organization of the Skin Immune System and Compartmentalized Immune Responses in Infectious Diseases

    The skin is an organ harboring several types of immune cells that participate in innate and adaptive immune responses. The immune system of the skin comprises both skin cells and professional immune cells that together constitute what is designated skin-associated lymphoid tissue (SALT). In this review, I extensively discuss the organization of SALT and the mechanisms involved in its responses to infectious diseases of the skin and...

    Juarez Antonio Simões Quaresma
    31 Jul 2019

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Clinical Microbiology Reviews ® (CMR) analyzes the latest developments in clinical microbiology and immunology, providing the current state of knowledge in the field, as well as balanced, thought-provoking perspectives on controversial issues.

Cumitechs & Practical Guidance for Clinical Microbiology.

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