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Clinical Microbiology Reviews
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Latest Articles

  • Point-of-Care HIV Viral Load Testing: an Essential Tool for a Sustainable Global HIV/AIDS Response
    Review
    Point-of-Care HIV Viral Load Testing: an Essential Tool for a Sustainable Global HIV/AIDS Response

    The global public health community has set ambitious treatment targets to end the HIV/AIDS pandemic. With the notable absence of a cure, the goal of HIV treatment is to achieve sustained suppression of an HIV viral load, which allows for immunological recovery and reduces the risk of onward HIV transmission.

    Paul K. Drain, Jienchi Dorward, Andrew Bender, Lorraine Lillis, Francesco Marinucci, Jilian Sacks, Anna Bershteyn, David S. Boyle, Jonathan D. Posner, Nigel Garrett
    15 May 2019
  • Extended Dosing Regimens for Fungal Prophylaxis
    Review
    Extended Dosing Regimens for Fungal Prophylaxis

    Invasive fungal diseases carry high morbidity and mortality in patients undergoing chemotherapy for hematological malignancies or allogeneic hematopoietic stem cell transplantation. In order to prevent these life-threatening infections, antifungal chemoprophylaxis plays an important role in daily clinical practice.

    Thomas Lehrnbecher, Konrad Bochennek, Thomas Klingebiel, Silke Gastine, Georg Hempel, Andreas H. Groll
    15 May 2019
  • Hypervirulent <span class="named-content genus-species" id="named-content-1">Klebsiella pneumoniae</span>
    Review
    Hypervirulent Klebsiella pneumoniae

    Hypervirulent K. pneumoniae (hvKp) is an evolving pathotype that is more virulent than classical K. pneumoniae (cKp). hvKp usually infects individuals from the community, who are often healthy.

    Thomas A. Russo, Candace M. Marr
    15 May 2019
  • Microorganisms in the Placenta: Links to Early-Life Inflammation and Neurodevelopment in Children
    Review
    Microorganisms in the Placenta: Links to Early-Life Inflammation and Neurodevelopment in Children

    Prenatal exposure to various stressors can influence both early and later life childhood health. Microbial infection of the intrauterine environment, specifically within the placenta, has been associated with deleterious birth outcomes, such as preterm birth, as well as adverse neurological outcomes later in life.

    Martha Scott Tomlinson, Kun Lu, Jill R. Stewart, Carmen J. Marsit, T. Michael O’Shea, Rebecca C. Fry
    1 May 2019
  • Factors That Influence the Immune Response to Vaccination
    Review
    Factors That Influence the Immune Response to Vaccination

    There is substantial variation between individuals in the immune response to vaccination. In this review, we provide an overview of the plethora of studies that have investigated factors that influence humoral and cellular vaccine responses in humans.

    Petra Zimmermann, Nigel Curtis
    13 Mar 2019
  • <span class="named-content genus-species" id="named-content-1">Candida parapsilosis</span>: from Genes to the Bedside
    Review
    Candida parapsilosis: from Genes to the Bedside

    Patients with suppressed immunity are at the highest risk for hospital-acquired infections. Among these, invasive candidiasis is the most prevalent systemic fungal nosocomial infection.

    Renáta Tóth, Jozef Nosek, Héctor M. Mora-Montes, Toni Gabaldon, Joseph M. Bliss, Joshua D. Nosanchuk, Siobhán A. Turner, Geraldine Butler, Csaba Vágvölgyi, Attila Gácser
    27 Feb 2019
  • Echinococcosis: Advances in the 21st Century
    Review
    Echinococcosis: Advances in the 21st Century

    Echinococcosis is a zoonosis caused by cestodes of the genus Echinococcus (family Taeniidae). This serious and near-cosmopolitan disease continues to be a significant public health issue, with western China being the area of highest endemicity for both the cystic (CE) and alveolar (AE) forms of echinococcosis.

    Hao Wen, Lucine Vuitton, Tuerhongjiang Tuxun, Jun Li, Dominique A. Vuitton, Wenbao Zhang, Donald P. McManus
    13 Feb 2019
  • Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Prosthetic Valve Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management
    Review
    Methicillin-Resistant Staphylococcus aureus Prosthetic Valve Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management

    Staphylococcus aureus prosthetic valve endocarditis (PVE) remains among the most morbid bacterial infections, with mortality estimates ranging from 40% to 80%. The proportion of PVE cases due to methicillin-resistant Staphylococcus aureus (MRSA) has grown in recent decades, to account for more than...

    Alicia Galar, Ana A. Weil, David M. Dudzinski, Patricia Muñoz, Mark J. Siedner
    13 Feb 2019
  • NDM Metallo-β-Lactamases and Their Bacterial Producers in Health Care Settings
    Review
    NDM Metallo-β-Lactamases and Their Bacterial Producers in Health Care Settings

    New Delhi metallo-β-lactamase (NDM) is a metallo-β-lactamase able to hydrolyze almost all β-lactams. Twenty-four NDM variants have been identified in >60 species of 11 bacterial families, and several variants have enhanced carbapenemase activity.

    Wenjing Wu, Yu Feng, Guangmin Tang, Fu Qiao, Alan McNally, Zhiyong Zong
    30 Jan 2019
  • <em>Escherichia coli</em> Pathobionts Associated with Inflammatory Bowel Disease
    Review
    Escherichia coli Pathobionts Associated with Inflammatory Bowel Disease

    Gut bacteria play a key role in initiating and maintaining the inflammatory process in the gut tissues of inflammatory bowel disease (IBD) patients, by supplying antigens or other stimulatory factors that trigger immune cell activation. Changes in the composition of the intestinal microbiota in IBD patients compared to that in healthy controls and a reduced diversity of intestinal microbial species are linked to the pathogenesis of IBD...

    Hengameh Chloé Mirsepasi-Lauridsen, Bruce Andrew Vallance, Karen Angeliki Krogfelt, Andreas Munk Petersen
    30 Jan 2019

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About CMR

Clinical Microbiology Reviews ® (CMR) analyzes the latest developments in clinical microbiology and immunology, providing the current state of knowledge in the field, as well as balanced, thought-provoking perspectives on controversial issues.

Cumitechs & Practical Guidance for Clinical Microbiology.

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